alpha-Conotoxin ImI is a conotoxin that has been found inC. imperialisand has receptor antagonist and anticancer activities.1It is a peptide antagonist of homomeric alpha7 nicotinic acetylcholine receptors (nAChRs, IC50= 220 nM). alpha-Conotoxin ImI is selective for alpha7 nAChRs over alpha2beta2, alpha3beta2, alpha4beta2, alpha2beta4, alpha3beta4, alpha4beta4, and alpha1beta1gammadelta subunit-containing nAChRs at 5 µM but does inhibit homomeric alpha9 nAChRs (IC50= 1,800 nM). Administration of paclitaxel in micelles containing alpha-conotoxin ImI decreases tumor growth in an MCF-7 mouse xenograft model.2Intracerebroventricular, but not intraperitoneal, administration of alpha-conotoxin ImI (20 nmol/animal) induces seizures in rats.3
Target:
Others
* VAT and and shipping costs not included. Errors and price changes excepted
