19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 &181M, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 &181M.
Molecular Weight:
523.626
CAS Number:
[191349-10-7]
Formula:
C30H37NO7
Target:
Others|||Endogenous Metabolite|||Parasite
T35483
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