Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. ()13(14)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 13,14-double bond of DHA. It has been detected in rat brain and spinal cord and is a preferred substrate for soluble epoxide hydrolase with a Km value of 3.2 µM. ()13(14)-EpDPA demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models. ()13(14)-EpDPA and other epoxy metabolites of DHA are also reported to potently inhibit angiogenesis and tumor growth in in vitro assays.
Molecular Weight:
344.495
CAS Number:
[895127-64-7]
Formula:
C22H32O3
Target:
Others|||Cytochromes P450
T35496
* VAT and and shipping costs not included. Errors and price changes excepted
