X-376 is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins, and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development.
Molecular Weight:
547.41
Purity:
97.87%
CAS Number:
[1365267-27-1]
Formula:
C25H25Cl2FN6O3
Target:
ALK|||c-Met/HGFR
T3550
* VAT and and shipping costs not included. Errors and price changes excepted
