()12-HEPE is produced by non-enzymatic oxidation of EPA, resulting in equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of ()12-HEPE is likely mediated by one of the individual isomers, primarily the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with an IC50 of 24 µM, similar to 12-HETE (IC50 = 25 µM), and both compounds also inhibit U46619-induced contraction of rat aorta with IC50 values between 8.6-8.8 µM. [1][2]
Molecular Weight:
318.457
CAS Number:
[81187-21-5]
Formula:
C20H30O3
Target:
Prostaglandin Receptor|||Others
T35506
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