Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. ()17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. At a concentration of 2 µM the (S)-enantiomer of 17-HETE inhibits proximal tubule ATPase activity by as much as 70%, whereas the (R)-isomer is inactive.
Molecular Weight:
320.473
CAS Number:
[128914-47-6]
Formula:
C20H32O3
Target:
ATPase|||Cytochromes P450|||Others
T35523
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