Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50value of 5 µM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-beta-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 µM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 µM) increases levels of troponin T (TnnT), a marker of cardiomyocyte differentiation, in human induced pluripotent stem cells (iPSCs) stimulated with BMP4 and the glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021 .
Molecular Weight:
402.44
CAS Number:
[2247911-68-6]
Formula:
C24H22N2O4
Target:
Others|||Lipoxygenase
T35541
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