PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 µM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 µM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and lambda-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times.
Molecular Weight:
473.99
CAS Number:
[128837-71-8]
Formula:
C25H32ClN3O4
Target:
Others|||Serine Protease
T35579
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