4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 µM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 µM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 µM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.
Molecular Weight:
582.853
CAS Number:
[1214886-31-3]
Formula:
C34H50O6Si
Target:
Others|||Apoptosis
T35647
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