Marcfortine A, an indole alkaloid originally isolated from P. roqueforti, exhibits nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 µg/ml) and inhibits motility of adult worms (EC50 = 2 µM). It effectively eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively). Marcfortine A also dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing alpha3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.
Molecular Weight:
477.605
CAS Number:
[75731-43-0]
Formula:
C28H35N3O4
Target:
Parasite|||Others
T35745
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