PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR, IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimers disease.4
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