5-Benzyloxygramine is an N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities. It stabilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners, resulting in abnormal N protein oligomerization, which was further confirmed in cell studies[1]. [1]. Shan-Meng Lin, et al. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. J Med Chem. 2020 Mar 26,63(6):3131-3141.
Molecular Weight:
280.36
Purity:
99.13%
CAS Number:
[1453-97-0]
Formula:
C18H20N2O
Target:
5-HT Receptor|||Dopamine Receptor|||Antibiotic
T35841
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