PKI-179 is a potent, orally active compound that functions as a dual PI3K/mTOR inhibitor. It demonstrates IC50 values of 8 nM for PI3K-alpha, 24 nM for PI3K-beta, 74 nM for PI3K-gamma, 77 nM for PI3K-delta, and 0.42 nM for mTOR. Additionally, it is effective against E545K and H1047R mutations, with IC50s of 14 nM and 11 nM, respectively. In vivo studies have shown that PKI-179 possesses anti-tumor capabilities[1][2].
Molecular Weight:
488.54
CAS Number:
[1197160-28-3]
Formula:
C25H28N8O3
Target:
Others|||PI3K|||mTOR
T36084
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