Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases (IC50 = 5 nM), thereby blocking vacuolar organelle acidification and early to late endosomal transport. It interferes with bone resorption, maturation of CD8 T lymphocytes, and prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting MHC class II molecule expression on the cell surface.
Molecular Weight:
852.072
CAS Number:
[81552-33-2]
Formula:
C45H73NO14
Target:
Proton pump|||Others|||Antibiotic
T36116
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