Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid . In mammals, 12(R)-HETE can be produced by 12(R)-LOs and also by CYP450 oxidation. The activity of 12(R)-HETE in mammals is predominantly proinflammatory. 12(R)-HETE exhibits dose-dependent leukocyte chemotaxis at concentrations as low as 100 nM, and lowers intraocular pressure in rabbits.
Molecular Weight:
320.47
CAS Number:
[82337-46-0]
Formula:
C20H32O3
Target:
Others|||Aryl Hydrocarbon Receptor|||ATPase
T36145
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