Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells.
Molecular Weight:
582.96
Purity:
98.71%
CAS Number:
[1448347-49-6]
Formula:
C28H22ClF3N6O3
Target:
Dehydrogenase|||Isocitrate Dehydrogenase (IDH)
T3617
* VAT and and shipping costs not included. Errors and price changes excepted