Azelaoyl PAF is a potent PPARgamma agonist that competitively binds thiazolidinediones with potency comparable to rosiglitazone. In atherosclerosis studies, Azelaoyl PAF promotes the uptake of oxidized low-density lipoprotein (oxLDL) by macrophages by upregulating CD36 expression. In fibroblasts from Friedreichs ataxia (FRDA) patients, Azelaoyl PAF significantly increased mRNA and protein levels of ferritin.
Molecular Weight:
651.85
CAS Number:
[354583-69-0]
Formula:
C33H66NO9P
Target:
PPAR|||Integrin
T36180
T36180
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