CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM. It has activity at multiple oncogenic kinases, with IC50 values less than 50 nM against wild-type EGFR and ABL and mutant ABLG250E, ABLY253F, ABLE255K, and B-RafV600E. CAY10717 is highly cytotoxic against a cancer cell panel that includes chemotherapy-sensitive and -resistant cell lines (EC50s = 0.4-158 nM). It also inhibits the growth of human umbilical vein endothelial cells (HUVECs, EC50 = 34 nM), a model for tumor angiogenesis.
Molecular Weight:
562.54
CAS Number:
[1240322-54-6]
Formula:
C29H25F3N6O3
Target:
Others|||VEGFR|||EGFR|||Src|||Raf
T36193
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