Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT, IC50 = 0.8 µg/ml).1 It is selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-beta-hydroxylase at 100 µg/ml. Methylspinazarin decreases blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg.
Molecular Weight:
236.18
CAS Number:
[41768-12-1]
Formula:
C11H8O6
Target:
Others|||Transferase
T36207
T36207
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