6alpha-Prostaglandin I1 (6alpha-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. It promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration-dependent manner but is about 10-fold less potent than the beta-isomer and 100-fold less potent than PGI2 in eliciting this response. 6alpha-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, nearly 900-fold higher than that of PGI2 (0.4 ng/ml).
Molecular Weight:
354.487
CAS Number:
[62777-90-6]
Formula:
C20H34O5
Target:
Prostaglandin Receptor|||Others
T36238
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