6beta-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6beta-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6beta-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 µM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.
Molecular Weight:
354.487
CAS Number:
[62770-50-7]
Formula:
C20H34O5
Target:
Others|||Prostaglandin Receptor
T36239
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