Selective peptide-based beta-catenin Degrader. Comprises a beta-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces beta-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades beta-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids.
Target:
PROTACs|||APC/C|||Wnt/beta-catenin
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