PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay, 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhibiting autotaxin, reduces LPA levels both in plasma and at the site of inflammation.
Molecular Weight:
478.33
Purity:
98.70%
CAS Number:
[1144035-53-9]
Formula:
C22H21Cl2N3O5
Target:
PDE
T3631
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