C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 µM. C6 urea ceramide decreases total beta-catenin, increases phosphorylated beta-catenin, and induces colocalization of beta-catenin with the 20S proteasome in HT-29 and HCT116, but not RIE-1, cells. It reduces tumor growth and increases C16, C18, C20, and C24 ceramide levels in tumor tissue in an HT-29 mouse xenograft model when administered at doses of 1.25, 2.5, and 5 mg/kg for five days.
Molecular Weight:
426.68
CAS Number:
[486991-52-0]
Formula:
C25H50N2O3
Target:
Apoptosis|||Others|||Autophagy|||Wnt/beta-catenin
T36321
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