Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinsons, Alzheimers, and prion diseases. A screen for protective activity against ER stress-dependent cell death identified termitomycamides, extracts from the fruiting bodies of T. titanicus, a notably large edible mushroom that is cultivated symbiotically in the nests of termites Termitomycamide B is a fatty acid isolated from T. titanicus that at a dose of 0.1 µg/ml protects against ER stress-dependent cell death in Neuro2a cells induced by tunicamycin.
Molecular Weight:
436.63
CAS Number:
[1254277-89-8]
Formula:
C28H40N2O2
Target:
Others|||GPCR
T36328
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