Dios-Arg (trifluoroacetate salt), CAS [[1807353-31-6]]

Product Overview

• Article Name: Dios-Arg (trifluoroacetate salt), CAS [[1807353-31-6]]
• Biozol Catalog Number: TGM-T36359
• Supplier Catalog Number: T36359
• Alternative Catalog Number: TGM-T36359-1MG,TGM-T36359-5MG,TGM-T36359-10MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratio greater than or equal to 4. Dios-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence and absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-beta-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein . It has been used, coupled to 1,2-dioleoyl-sn-glycero-3-PE , to bind siRNA and plasmid DNA to form cationic lipid nanoparticles for intracellular transport. Dios-Arg is cytotoxic to H1299 and HeLa cells (IC50s = 83.5 and 74.1 µg/ml, respectively).

Product Properties

• Molecular Weight: 912.01
• CAS Number: [1807353-31-6]
• Formula: C43H67F6N5O9
• Target: Others|||Liposome

Images

T36359