SB-612111 is a novel and potent human opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki = 0.33 nM). It exhibits selectivity for µ-, kappa-, and delta-receptors with Ki values of 57.6 nM, 160.5 nM, and 2109 nM, respectively. SB-612111 effectively antagonizes the pronociceptive action of Nociceptin in an acute pain model[1].
Molecular Weight:
418.4
CAS Number:
[371980-98-2]
Formula:
C24H29Cl2NO
Target:
Others|||Opioid Receptor
T36376
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