ZQ-16 is a potent and highly selective agonist for the G protein-coupled receptor GPR84, demonstrating a half-maximal effective concentration (EC50) of 0.213 µM, and it activates multiple downstream signaling pathways including calcium mobilization, inhibition of cAMP accumulation, phosphorylation of extracellular signal-regulated protein kinase 1/2 (ERK1/2), receptor desensitization and internalization, and receptor-beta-arrestin interaction, making it a useful tool compound for studying GPR84 function and a candidate for further optimization.
Molecular Weight:
228.31
Purity:
98.52%
CAS Number:
[376616-73-8]
Formula:
C10H16N2O2S
Target:
GPCR
T36634
T36634
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