Naphthofluorescein (Naphthafluorescein) is a Mint3 inhibitor with potential antitumor and anti-inflammatory activities, inhibits the interaction between HIF-1 and Mint3, inhibits Mint3-dependent HIF-1 activity, and inhibits glycolytic activity in cancer cells and macrophages without showing significant in vitro cytotoxicity or in vivo side effects. Naphthofluorescein is also a fluorescent pH-sensitive probe for functional Cherenkov imaging.
Molecular Weight:
432.42
Purity:
99.34%
CAS Number:
[61419-02-1]
Formula:
C28H16O5
Target:
HIF|||HIF/HIF Prolyl-Hydroxylase
T36953
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