AS-99 is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 µM, Kd= 0.89 µM) with anti-leukemic activity, blocking cell proliferation, inducing apoptosis and differentiation, downregulating MLL fusion target genes, and reducing the leukemia burden in vivo[1].
Molecular Weight:
593.68
CAS Number:
[2323623-93-2]
Formula:
C27H30F3N5O3S2
Target:
Apoptosis|||Histone Methyltransferase|||Others
T36977
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