Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or dsDNA-bound forms, with reduced affinity compared to 23-cGAMP or 33-cGAMP .1,2Cyclic di-UMP is intended for use as a negative control for cyclic di-GMP signaling.
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