7beta,27-dihydroxy Cholesterol, CAS [[240129-43-5]]

Product Overview

• Article Name: 7beta,27-dihydroxy Cholesterol, CAS [[240129-43-5]]
• Biozol Catalog Number: TGM-T36998
• Supplier Catalog Number: T36998
• Alternative Catalog Number: TGM-T36998-1MG,TGM-T36998-500UG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: 7beta,27-DHC , 7beta,27-dihydroxy Cholesterol

Product Description

7beta,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor gamma (RORgamma) and RORgammat. [1] It activates RORgamma- or RORgammat-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7beta,27-dihydroxy Cholesterol is selective for RORgamma and RORgammat over a panel of eight additional nuclear receptors at 30 &181M. It increases IL-17A production in Th17-polarized isolated human na ve CD4+ T cells when used at a concentration of 300 nM. 7beta,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse gammadelta T cells stimulated with 12-myristate 13-acetate and ionomycin .

Product Properties

• Molecular Weight: 418.65
• CAS Number: [240129-43-5]
• Formula: C27H46O3
• Target: ROR|||Others

Images

T36998