12(S)-HETE, a 12-lipoxygenase metabolite of arachidonic acid, is mitogenic for cancer cell proliferation and enhances angiotensin II-induced contraction of BLT2 (type 2 receptor in arteries of leukotriene B4 mice) and TP (thromboxane receptor)-mediated mechanisms. 12(S)-HETE promotes superoxide and isothromboxane-like metabolites in arterial endothelial cells. production.
Molecular Weight:
320.47
CAS Number:
[54397-83-0]
Formula:
C20H32O3
Target:
ERK|||DNA/RNA Synthesis|||p38 MAPK
T37047
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