20-HEPE, a metabolite of eicosapentaenoic acid, is formed via omega-oxidation of EPA by cytochrome P450 (CYP) omega-oxidases, including human CYP4F3B. It activates peroxisome proliferator-activated receptor alpha (PPARalpha) in COS-7 cells expressing a luciferase reporter at a concentration of 10 µM. 20-HEPE also activates murine transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks antinociceptive activity in rats.
Molecular Weight:
318.457
CAS Number:
[116477-57-7]
Formula:
C20H30O3
Target:
PPAR|||Others
T37092
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