(Z)-4EGI-1, the Z-isomer of 4EGI-1, serves as an inhibitor of both the eIF4E/eIF4G interaction and translation initiation. It effectively binds to eIF4E, exhibiting an IC50 of 43.5 µM and a Kd value of 8.74 µM. Notably, (Z)-4EGI-1 possesses anticancer activity[1][2].
Molecular Weight:
451.28
CAS Number:
[901787-88-0]
Formula:
C18H12Cl2N4O4S
Target:
Others|||PERK
T37099
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