D-erythro/L-threo Lysosphingomyelin (d18:1), CAS [[82970-80-7]]

Product Overview

• Article Name: D-erythro/L-threo Lysosphingomyelin (d18:1), CAS [[82970-80-7]]
• Biozol Catalog Number: TGM-T37187
• Supplier Catalog Number: T37187
• Alternative Catalog Number: TGM-T37187-5MG,TGM-T37187-10MG,TGM-T37187-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: D-erythro/L-threo Lysosphingomyelin (d18:1)

Product Description

Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50= ~35 nM).4Levels of D-erythrolysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B.2,5L-threolysosphingomyelin is also an S1P1-3agonist (EC50s = 19.3, 131.8, and 313.3 nM, respectively).3This product is a mixture of D-erythroand L-threolysosphingomyelin.

Product Properties

• Molecular Weight: 464.62
• CAS Number: [82970-80-7]
• Formula: C23H49N2O5P
• Target: Others

Images

T37187

T37187