CAY10787 is an oxysterol and a negative allosteric modulator of GABAAreceptors.1,2It reduces GABA-induced currents in HEK cells expressing alpha1beta1gamma2or alpha4beta3gamma2subunit-containing GABAAreceptors (IC50s = 1.5 and 1 µM, respectively).2CAY10787 (500 nM) reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons.
Molecular Weight:
382.632
CAS Number:
[567-72-6]
Formula:
C27H42O
Target:
Others|||GABA Receptor
T37201
* VAT and and shipping costs not included. Errors and price changes excepted
