()8,9-DiHETE is a major metabolite of the 20:5 omega-3 fatty acid eicosapentaenoic acid .[1] It is produced in rat liver microsomes, but not renal microsomes, by the generation of the unstable intermediate 8,9-epoxy eicosatetraenoic acid from EPA by cytochrome P450 monooxygenases. Dietary EPA supplementation in humans results in substantial urinary excretion of vicinal diols, including 8,9, 11,12, and 14,15 forms.[2]
Molecular Weight:
336.472
CAS Number:
[867350-87-6]
Formula:
C20H32O4
Target:
Others
T37229
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