EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as ()14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. ()16(17)-EpDPA is the DHA homolog of ()14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA. The EDHF activity of ()16(17)-EpDPA has not yet been determined. The epoxygenase metabolites of DHA have also been detected in a mouse inflammation model.[4]
Molecular Weight:
344.495
CAS Number:
[155073-46-4]
Formula:
C22H32O3
Target:
Others
T37235
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