GoSlo-SR-5-69 is a potent high-conductance calcium-activated potassium channel (BK channel) agonist, with an EC50 of 251 nM. GoSlo-SR-5-69 significantly shifts the voltage required for half-maximal activation in a negative direction (deltaV1/2 = -104 mV), thereby enhancing channel open probability. Widely used in studies of neuronal excitability, vasodilation, smooth muscle regulation, and ion channel pharmacology, it elucidates BK channel function under physiological and pathological conditions.
Molecular Weight:
470.47
Purity:
99.73%
CAS Number:
[1363419-31-1]
Formula:
C24H19N2NaO5S
Target:
Potassium Channel
T37294
T37294
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