JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210, which is converted to butyronitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in the same manner as ML-210 and is completely rescued by ferroptosis inhibitors.
Molecular Weight:
451.3
Purity:
98.72%
CAS Number:
[2421119-60-8]
Formula:
C20H20Cl2N4O4
Target:
Glutathione Peroxidase|||GPX|||Ferroptosis
T37314
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