6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil . It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6. It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 µM in HEK293 cells expressing hERG).
Molecular Weight:
365.47
CAS Number:
[120013-56-1]
Formula:
C23H27NO3
Target:
Potassium Channel|||Others|||Drug Metabolite
T37360
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