ASIC blocker (IC50 values are 0.44, 2.1 µM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 µM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3, IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.
Molecular Weight:
321.37
CAS Number:
[309711-59-9]
Formula:
C19H19N3O2
Target:
Sodium Channel|||Others
T37389
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