High affinity alpha7 nAChR partial agonist (Ki = 1.1 nM in rat, Emax < 10% of the response to ACh in rat and human). Inhibits ACh (IC50 = 2.7 nM) at alpha7 nAChR. Reduces LPS-induced TNF-alpha release from microglia enriched cultures. Anti-inflammatory.
Molecular Weight:
400.83
CAS Number:
[753499-14-8]
Formula:
C19H20ClF3N2O2
Target:
Others
T37390
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