(+)-Macrosphelide A is a fungal metabolite originally isolated from Microsphaeropsis. It inhibits adhesion of HL-60 human leukemia cells to human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner. It also inhibits the growth of SKOV3 ovarian cancer cells in a concentration-dependent manner. (+)-Macrosphelide A inhibits the growth of Gram-positive bacteria, including B. subtilis, M. luteus, B. thuringiensis, and S. aureus (MICs = 143, 143, 57, and 57 µg/ml, respectively), but not Gram-negative bacteria or fungi.
Molecular Weight:
342.344
CAS Number:
[172923-77-2]
Formula:
C16H22O8
Target:
Others|||Antibiotic
T37552
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