Nidulin is a depsidone originally isolated from A. nidulans. It is active against the bacteria M. tuberculosis and M. ranoe, as well as the fungi T. tonsurans and M. audouini. It also inhibits the growth of methicillin-resistant S. aureus (MRSA, MIC = 4 µg/ml) and has larvicidal activity toward Artemia (LC50 = 2.8 µg/ml). Nidulin is cytotoxic to MOLT-3 cells (IC50 = 21.2 µM) but not HuCCA-1, HepG2, or A549 cells (IC50s = >112.7 µM). It inhibits aromatase with an IC50 value of 11.2 µM.
Molecular Weight:
443.7
CAS Number:
[10089-10-8]
Formula:
C20H17Cl3O5
Target:
Others|||Antifungal|||Antibacterial
T37560
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