Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken alpha3beta4-, alpha4beta2-, and alpha7-containing nAChRs.2 Dietary administration of aspergillimide A (10 µg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces T. colubriformis fecal egg count in gerbils.3
Molecular Weight:
359.47
CAS Number:
[195966-93-9]
Formula:
C20H29N3O3
Target:
Others|||AChR
T37609
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