Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-alpha-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-kappaB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.
Molecular Weight:
116.07
Purity:
99.28%
CAS Number:
[110-17-8]
Formula:
C4H4O4
Target:
Endogenous Metabolite|||p38 MAPK|||NF-kappaB
T3763
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