JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .
Molecular Weight:
451.3
CAS Number:
[2421118-05-8]
Formula:
C20H20Cl2N4O4
Target:
Others|||Ferroptosis|||Glutathione Peroxidase
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