LEO 39652, a dual-soft PDE4 inhibitor, demonstrates potent inhibition of PDE4 subtypes A, B, C, and D with respective IC50 values of 1.2 nM, 1.2 nM, 3.0 nM, and 3.8 nM. Additionally, it inhibits TNF-alpha with an IC50 of 6.0 nM, indicating its potential for topical Atopic dermatitis (AD) research [1].
Molecular Weight:
421.45
CAS Number:
[1445656-91-6]
Formula:
C23H23N3O5
Target:
Others|||PDE
T38002
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